What medicine should be taken to turn stones away: hot topics and structured guide on the Internet in the past 10 days
Recently, drug selection for stone treatment has become a hot topic on the Internet. Combining the entire Internet search data and medical guidelines in the past 10 days, this article compiled a structured medication guide to help patients scientifically deal with stone problems.
1. Current hot-search list of stone treatment drugs
| Drug name | Hot search index | Applicable stone types |
|---|---|---|
| Sodium Potassium Hydrogen Citrate Granules | 48500 | uric acid stones |
| α-mercaptopropionylglycine | 32000 | cystine stones |
| sodium bicarbonate tablets | 27800 | Uric acid/cystine stones |
| Allopurinol tablets | 19500 | Uric acid stones (lowering uric acid) |
| Paishi granules (Chinese patent medicine) | 56200 | Adjuvant treatment for small stones |
2. Drug treatment options for different types of stones
| Stone type | drug of choice | Course of treatment | Things to note |
|---|---|---|---|
| uric acid stones | Citrate preparations | 3-6 months | Need to cooperate with urine alkalinization |
| cystine stones | α-mercaptopropionylglycine | long term maintenance | Need to drink lots of water |
| calcium oxalate stones | Thiazide diuretics | individualization | sodium restricted diet |
| calcium phosphate stones | Acetylhydroxyproline | 6-12 months | Control urinary tract infections |
3. Core precautions for drug use
1.Diagnosis first: The composition of the stones must be clarified through imaging and urinalysis before medication is administered.
2.dose control: Citrate preparations need to maintain urine pH at 6.5-7.0. Excessive use may induce other stones.
3.combination therapy: Medical treatment needs to be combined with drinking 2.5-3 liters of water per day and controlling diet (such as uric acid stones require a low-purine diet).
4.Regular review: B-ultrasound and urinalysis need to be reviewed every 3 months to evaluate the treatment effect.
4. The latest treatment progress in 2023
| New drug name | R&D stage | Mechanism of action | Estimated time to market |
|---|---|---|---|
| Lumasiran | Phase III clinical | Inhibit oxalic acid production | 2024 |
| Topiroxostat | Already on the market (Japan) | Selective xanthine oxidase inhibitor | - |
5. Key points of expert consensus
1. For stones with a diameter of less than 5 mm, drug removal can be attempted, and for stones with a diameter of > 10 mm, extracorporeal lithotripsy or surgery should be considered.
2. The effectiveness of Paishi Granules, a Chinese patent medicine, is about 68% for stones with a diameter of less than 4 mm, but it needs to be treated with Western medicine.
3. Taking alkaline drugs at night can better control the pH fluctuation of morning urine.
Warm reminder:The data in this article come from public medical literature and Internet hot search statistics. The specific medication plan needs to be formulated after evaluation by a urologist. Sudden renal colic or fever requires immediate emergency treatment.
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